Radiotherapie - oncologie - dr. Alex De Caluwé

de Caluwé A, Desmoulins I, Cao K, Remouchamps V, Baten A, Longton E, et al. Neoadjuvant stereotactic body radiation therapy with durvalumab and oleclumab in ER+HER2− breast cancer: a randomized phase 2 trial. Nat Med. 2026 Jun 25. doi:10.1038/s41591-026-04453-z

Baiden-Amissah REM, Tuyaerts S, Annibali D, Herreros-Pomares A, de Wispelaere W, Benedetto RM, ..., de Caluwé A, et al. Circulating immune cell profiling in advanced cervical and endometrial cancer patients treated with PD-1 blockade, radiotherapy, and immune modulation in the PRIMMO trial. Front Immunol. 2026;17:1794131. doi:10.3389/fimmu.2026.1794131 PubMed PMID: 42253973.

Catteau X, Noël JC, Fallas J, Charry M, Denis Z, de Caluwé A, et al. Descriptive study of stromal expression of CD73 in ductal carcinoma in situ of the breast. Discover Oncology. 2026 Dec 1;17(1). doi:10.1007/s12672-026-04959-5

Yin T, Lifrange F, Denis Z, de Caluwé A, Buisseret L, Catteau X, et al. Fully Automated Stain Quantification Framework for IHC Whole Slide Images in Breast Cancer. Technol Cancer Res Treat. 2026 Apr 3;25. doi:10.1177/15330338251407734

Cogels MM, Serra M, Duvillier H, Garaud S, Verset L, Venet D, ... de Caluwé A, et al. Immuno-radiotherapy enhances tumor control and induces abscopal responses in a humanized mouse model. Front Immunol. 2026;17. doi:10.3389/fimmu.2026.1774955

Arecco L, Cacilhas PM, Bobato Lara Gismondi C, Bruzzone M, Gentile G, Gerosa R, ... de Caluwé A, ... et al. Association between alcohol consumption and breast cancer incidence and prognosis: A systematic review and meta-analysis. Breast. Churchill Livingstone; 2026. doi:10.1016/j.breast.2026.104719

Cogels MM, de Caluwé A, Buisseret L, Penninckx S. Unlocking the therapeutic potential of immuno-radiotherapy: insights from preclinical and clinical research. Oncoimmunology. 2026. p. 2608436. doi:10.1080/2162402X.2025.2608436 PubMed PMID: 41491954.

Zamagni, A., Montero Luis, A., Mjaaland, I., Chirila, M. E., Ciervide, R., Machiels, M., Ratosa, I., van den Bongard, D. H. J. G., Aznar, M., Boersma, L. J., Coles, C. E., Corradini, S., Caluwe, A. de, Gabrys, D., Kaidar-Person, O., Kirby, A. M., Krug, D., Maraldo, M. v., Meattini, I., … Poortmans, P. (2026). ESTRO recommendations on preoperative radiation therapy in breast cancer: current and future perspectives – Endorsed by ASTRO. Radiotherapy and Oncology, 214. 

Potter, S., Avery, K., Ahmed, R., de Boniface, J., Chatterjee, S., Dodwell, D., Dubsky, P., Federmann, J., Finestone, S., Gnant, M., Hlauschek, D., Iwata, H., Jiang, M. Y., Kaidar-Person, O., Lee, H. B., MacKenzie, M., Meyn, A., Poortmans, P., Poulakaki, F., …de Caluwé, A, ... Abbott, N. (2025). A core outcome set for locoregional treatment reporting in neoadjuvant systemic breast cancer treatment trials. Npj Breast Cancer, 11(1).

Arecco, L., Gentile, G., Gerosa, R., Lambertini, M., Buisseret, L., de Caluwé, A., & de Azambuja, E. (2025). Immunotherapy in the neoadjuvant treatment of hormone receptor-positive/HER2-negative early breast cancer: novel approaches and future perspectives. Current Opinion in Oncology, 37(6).

de Caluwé, A., Bellal, S., Cao, K., Peignaux, K., Remouchamps, V., Baten, A., Longton, E., Bessieres, I., Vu-Bezin, J., Kirova, Y., Gestel, D. V., Desmoulins, I., Ignatiadis, M., Romano, E., Buisseret, L., Piccart, M., Vandekerkhove, C., Gulyban, A., & Poortmans, P. (2025). Adapting radiation therapy to immunotherapy: Delineation and treatment planning of pre-operative immune-modulating breast iSBRT in 151 patients treated in the randomized phase II Neo-CheckRay trial. Radiotherapy and Oncology, 206, 110836. 

Smine, Z., Poeta, S., de Caluwé, A., Desmet, A., Garibaldi, C., Brou Boni, K., Levillain, H., van Gestel, D., Reynaert, N., & Dhont, J. (2025). Automated segmentation in planning-CT for breast cancer radiotherapy: A review of recent advances. Radiotherapy and Oncology (Vol. 202). Elsevier Ireland Ltd.

de Jaeghere, E. A., Hamerlinck, H., Tuyaerts, S., Lippens, L., van Nuffel, A. M. T., Baiden-Amissah, R., Vuylsteke, P., Henry, S., Trinh, X. B., van Dam, P. A., Aspeslagh, S., de Caluwé, A., Naert, E., Lambrechts, D., Hendrix, A., de Wever, O., van de Vijver, K. K., Amant, F., Vandecasteele, K., … Denys, H. G. (2024). Associations of the gut microbiome with outcomes in cervical and endometrial cancer patients treated with pembrolizumab: Insights from the phase II PRIMMO trial. Gynecologic Oncology, 191, 275–286. 

de Caluwe, A., Romano, E., Poortmans, P., Gombos, A., Agostinetto, E., Marta, G. N., Denis, Z., Drisis, S., Vandekerkhove, C., Desmet, A., Philippson, C., Craciun, L., Veys, I., Larsimont, D., Paesmans, M., van Gestel, D., Salgado, R., Sotiriou, C., Piccart-Gebhart, M., … Buisseret, L. (2023). First-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial. Journal for ImmunoTherapy of Cancer, 11(12), e007279.

Pasquier, D., Bidaut, L., Oprea-Lager, D. E., Desouza, N. M., Krug, D., Collette, L., Kunz, W., Belkacemi, Y., Bau, M. G., Caramella, C., de Geus-Oei, L.-F., de Caluwé, A., Deroose, C., Gheysens, O., Herrmann, K., Kindts, I., Kontos, M., Kümmel, S., Linderholm, B., … Lecouvet, F. E. (2023). Policy Review Designing clinical trials based on modern imaging and metastasis-directed treatments in patients with oligometastatic breast cancer: a consensus recommendation from the EORTC Imaging and Breast Cancer Groups. The Lancet Oncolog.

Machiels, M., Oulkadi, R., Tramm, T., Stecklein, S. R., Somaiah, N., de Caluwé, A., Klein, J., Tran, W. T., & Salgado, R. (2023). Individualising radiation therapy decisions in breast cancer patients based on tumour infiltrating lymphocytes and genomic biomarkers. The Breast. 

Benkhaled, S., Diakité, K., Jullian, N., Poeta, S., Vandekerkhove, C., van Houtte, P., van Gestel, D., & de Caluwé, A. (2023). Boost modalities in cervical cancer: dosimetric comparison between intracavitary BT vs. intracavitary + interstitial BT vs. SBRT. Radiation Oncology, 18(1).

Debien, V., de Caluwé, A., Wang, X., Piccart-Gebhart, M., Tuohy, V. K., Romano, E., & Buisseret, L. (2023). Immunotherapy in breast cancer: an overview of current strategies and perspectives. npj Breast Cancer (Vol. 9, Issue 1). Nature Research. 

Wang, X., Collet, L., Rediti, M., Debien, V., de Caluwé, A., Venet, D., Romano, E., Rothé, F., Sotiriou, C., & Buisseret, L. (2023). Predictive Biomarkers for Response to Immunotherapy in Triple Negative Breast Cancer: Promises and Challenges. In Journal of Clinical Medicine (Vol. 12, Issue 3). MDPI.

Agostinetto, E., Jacobs, F., Debien, V., de Caluwé, A., Pop, C.-F., Catteau, X., Aftimos, P., de Azambuja, E., & Buisseret, L. (2022). Post-Neoadjuvant Treatment Strategies for Patients with Early Breast Cancer. Cancers, 14(21), 5467. 

de Jaeghere, E. A., Tuyaerts, S., van Nuffel, A. M. T., Belmans, A., Bogaerts, K., Baiden-Amissah, R., Lippens, L., Vuylsteke, P., Henry, S., Trinh, X. B., van Dam, P. A., Aspeslagh, S., de Caluwé, A., Naert, E., Lambrechts, D., Hendrix, A., de Wever, O., van de Vijver, K. K., Amant, F., … Denys, H. G. (2022). Pembrolizumab, radiotherapy, and an immunomodulatory five-drug cocktail in pretreated patients with persistent, recurrent, or metastatic cervical or endometrial carcinoma: Results of the phase II PRIMMO study. Cancer Immunology, Immunotherapy.

Philippson, C., Larsen, S., Simon, S., Vandekerkhove, C., de Caluwe, A., van Gestel, D., Chintinne, M., Veys, I., de Neubourg, F., Noterman, D., Roman, M., Nogaret, J. M., & Desmet, A. (2022). Intraoperative electron radiotherapy in early invasive ductal breast cancer: 6-year median follow-up results of a prospective monocentric registry. Breast Cancer Research, 24(1). 

Benkhaled, S., Gomes da Silveira Cauduro, C., Jullian, N., Desmet, A., Rodriguez, D., Jourani, Y., van Gestel, D., & de Caluwé, A. (2022). Inter-fraction heart displacement during voluntary deep inspiration breath hold radiation therapy without visual feedback measured by daily CBCT. Frontiers in Oncology, 12.

Salgado, R., Fineberg, S., De Caluwe, A., & de Azambuja, E. (2022). Tumour infiltrating lymphocytes and ductal carcinoma in situ: The art of thinking counterintuitively. European Journal of Cancer.

Stouthandel, M. E. J., Kayser, F., Vakaet, V., Khoury, R., Deseyne, P., Monten, C., Schoepen, M., Remouchamps, V., De Caluwé, A., Janoray, G., De Neve, W., Mazy, S., Veldeman, L., & Van Hoof, T. (2021). Delineation guidelines for the lymphatic target volumes in “prone crawl”  radiotherapy treatment position for breast cancer patients. Scientific Reports, 11(1), 22529. 

Imane, A., Gestel Dirk, V., Olga, K., Carine, K., Desmet, A., Catherine, P., Nick, R., & De Caluwé A. (2021). Unintended dose to the lower axilla in adjuvant radiotherapy for breast cancer: differences between tangential beam and VMAT. Radiotherapy and Oncology, 164, 282–288.

De Caluwé, A., Buisseret, L., Poortmans, P., Van Gestel, D., Salgado, R., Sotiriou, C., Larsimont, D., Paesmans, M., Craciun, L., Stylianos, D., Vandekerckhove, C., Reyal, F., Isabelle, V., Eiger, D., Piccart, M., Romano, E., & Ignatiadis, M. (2021). Neo-CheckRay: radiation therapy and adenosine pathway blockade to increase benefit of immuno-chemotherapy in early stage luminal B breast cancer, a randomized phase II trial. BMC Cancer, 21(1), 1–9.

Tuyaerts, S., Nuffel, A. M. T. Van, Naert, E., Dam, P. A. Van, Vuylsteke, P., De Caluwé A., Vandecasteele Katrien, Denys Hannelore (2019). PRIMMO study protocol : a phase II study combining PD-1 blockade , radiation and immunomodulation to tackle cervical and uterine cancer. 1–10.

Meattini, I., Lambertini, M., Desideri, I., De Caluwé A., Kaidar-Person, O., & Livi, L. (2019). Radiation therapy for young women with early breast cancer: Current state of the art. Critical Reviews in Oncology/Hematology, 137(September 2018), 143–153. 

De Caluwé A, Termote, K., Gestel, D. Van, & Limbergen, E. Van. (2018). Dose-response in choroidal melanoma. Radiotherapy and Oncology, 127, 374–378.

De Caluwé A, Bowering G, Nichol A, Hsu F. The incidence of symptomatic brain metastases from extra-pulmonary small cell carcinoma: Is there a role for prophylactic cranial irradiation in a clinically relevant population cohort? Radiotherapy and Oncology; July 2017

Hsu F, De Caluwé A, Anderson D, Nichol A, Toriumi T , Ho C. Patterns of spread and prognostic implications of lung cancer metastases: a population-based study in an era of driver mutations. Current Oncology; 2017

Hsu F, Alan N, Toriumi T, De Caluwé A. Miliary metastases are associated with epidermal growth factor receptor mutations in non-small cell lung cancer : a population-based study. Acta Oncologica (May 2017):1–6

Hsu F, De Caluwé A, Anderson D, Nichol A, Toriumi T, Ho C. EGFR mutation status on brain metastases from non-small cell lung cancer. Lung Cancer; 96:101-7; June 2016.

De Caluwé A, Junius S, Malleux G, Deroose C, Heye S, Verslype C, Van Cutsem E, Wildiers H, Prenen H, Paridaens R, Haustermans K. Selective Internal Radiotherapy with Yttrium-90 Microspheres for Primary and Metastatic Liver Cancer.  Belgian Journal of Medicine, 67, nr. 3, 2011.